Intelligent Systems Research (United States)

Latent causal diffusions for single-cell perturbation modeling

Perturbation screens hold the potential to systematically map regulatory processes at single-cell resolution, yet modeling and predicting transcriptome-wide responses to perturbations remains a major computational challenge. Existing methods often underperform simple baselines, f...

STiLE: Automated Tissue Microarray Dearraying for Spatial Transcriptomics

Tissue microarrays (TMAs) enable high-throughput spatial transcriptomic profiling of dozens of tissue cores on a single slide. However, existing dearraying methods operate on histological images and do not support the coordinate-based outputs of spatial transcriptomics platforms....

Formation control for multiple similar autonomous underwater vehicles with dynamic gaps via deep reinforcement learning

Dynamic gaps between simulation and real world environments are the major challenge for the implementation of deep reinforcement learning (RL) based formation control methods in systems composed of multiple similar autonomous underwater vehicles (AUVs), mainly involving hydrodyna...

Integer Ambiguity Resolution Based on Capuchin-Cuckoo Cooperative Search Algorithm and Enhanced Sharpness-Adaptive Ratio Test

In GNSS carrier-phase observations, rapid and accurate integer ambiguity resolution is essential for centimeter-level positioning. With BeiDou-3 and Galileo operational, rising dimensionality challenges LAMBDA with exponential complexity and heavy dependence on float-solution qua...

Ergodic control of multi-agent systems under communication constraints

We study decentralised ergodic control for multi-agent systems operating over stochastic, lossy communication graphs. Each agent follows controlled stochastic dynamics with uniformly elliptic noise on a compact domain and aims to align its occupation measure with a prescribed tar...

Non-RA screening for systemic autoimmune rheumatic diseases using a machine learning model based on physical findings and blood test data

Abstract Background In patients with systemic autoimmune rheumatic diseases (SARDs), particularly patients with non-rheumatoid arthritis (non-RA), the incidence of severe conditions such as interstitial pneumonia and pulmonary arterial hypertension is high. Therefore, early refer...