Integrated Cardio Metabolic Centre

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

The target-engagement predictor, implemented within the InSilicoTrials cloud-based, AI-powered platform for model-informed drug discovery and development, enables early exploration of time-dependent pharmacological responses. Predictions can be generated using inputs ranging from...

Effect of chocolate preference and cocoa content on experimentally induced muscle pain

Abstract Objectives Chocolate consumption has been associated with pain reduction, but it remains unclear whether this effect depends on cocoa concentration or individual preference. This study aimed to investigate whether chocolate preference and/or cocoa content modulate experi...

Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despite extensive research, treatment options...

Health4Life: a digital intervention to promote healthy diet and movement behaviours from the start of life: protocol for a hybrid effectiveness-implementation study

Abstract Background Globally and in Sweden childhood overweight and obesity remain major public health issues. The first 1000 days (i.e., conception-24 months) has been identified as the period of greatest developmental plasticity, with the maximum capacity to influence health th...