InSysBio (Russia)

Implementation of an Internalized Hemolysis Assessment Approach in Targeted Bottom-Up Proteomics for the Purpose of Blood Plasma Sample Quality Control

Abstract Mishandling of samples during blood plasma preparation may lead to biases in proteomic analysis and misinterpretation of data. An earlier study by Geyer et al. (2019) described proteins that may indicate poor plasma sample quality. Following this work, we have imitated a...

From Oncolysis to Adaptive Immunity: Yellow Fever Virus 17D and Ruxolitinib Activate Antitumor Immune Responses in Pancreatic Cancer Models

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, with a five-year survival rate of less than 12%. Oncolytic viruses are considered a promising immunotherapeutic approach, but their effectiveness is often limited by the innate interferon...