Instituto Superior da Maia

Phenolic Profiling and OECD-Guided Acute and Subacute Oral Toxicity Assessment of Cannabis sativa L. Seed Hydroethanolic Extract

Cannabis sativa L. seeds have been traditionally used in Moroccan folk medicine and are increasingly recognized as a valuable source of nutrients and bioactive phytochemicals with promising therapeutic properties. Despite their widespread traditional and nutritional use, scientif...

Hypobaric hypoxia at 3,466 m suppresses hepatic bile acid metabolism and remodels the tumor lipidome in mice

Abstract Background Systemic hypoxia induces whole-body metabolic adaptation, but its impact on tumor metabolism and hepatic bile acid (BA) pathways remains poorly defined. Methods We investigated how high-altitude (HA) hypobaric hypoxia at 3,466 m affects tumor growth, tumor lip...

Using Match Reference Values of External Load to Monitor Performance and Fatigue in Football: Are We Looking the Right Way?

Abstract Monitoring external load is critical for informed decision-making processes across sports. In football, external load is routinely monitored during training sessions and competitive matches. Matches are typically given particular emphasis, as they are generally associate...

Development and investigation of a NiO/ZnO@PPy-modified glassy carbon electrode for electrochemical sensing of metronidazole in environmental samples: Experimental and DFT studies

Metronidazole (MTZ) is widely prescribed as an antimicrobial drug, and its extensive use in animal farming has led to its accumulation in the environment, posing significant risks to human health and the environment. In this study, nickel and zinc oxide (NiO/ZnO) composite materi...

Biological Activities and In Silico Molecular Docking of an Aqueous Extract of Nigella sativa L. Seeds: A Focus on Antioxidant, Cytotoxic, and Diuretic Effects

Background: Nigella sativa L. is a medicinal plant widely recognized for its diverse pharmacological properties. This study aimed to evaluate the antioxidant, diuretic, and cytotoxic effects of an aqueous seed extract and its effects on selected biochemical parameters in rats. Th...

Ecological and Quality Conditions for Children’s Participation as a Right in Early Childhood Education and Care

Abstract Providing space for children’s voices to be heard, listening to their ideas and giving due weight to their propositions, on all matters that affect them, describes the concept of participation rights according to the United Nations Convention of the Rights of the Child....

Assessment of groundwater quality through hydrochemical and spatial analysis for domestic and agricultural uses

Abstract Groundwater plays a crucial role in Southeastern Morocco, where arid climate conditions, recurrent droughts, and increasing agricultural demands make it the primary source of water for domestic and irrigation purposes. In the absence of previous studies on the Bouanane w...

Synthesis of low-cost hierarchical zeolite 13X structure from abundant natural bentonite for efficient adsorption of polyphenols from olive mill wastewater

Olive mill wastewater (OMW), rich in polyphenols, poses environmental challenges due to toxicity and biodegradation resistance. This study synthesized Zeolite 13X from natural bentonite via alkaline fusion at 550 °C with 2.0 M NaOH and hydrothermal treatment at 100 °C for 48 h. X...

From soil disruption to biodegradation: A comprehensive review of microplastic effects and microbial breakdown mechanisms in terrestrial ecosystems

Abstract Microplastics (MPs) are pervasive in the environment, posing a significant global environmental challenge. Agricultural ecosystems are particularly vulnerable to MP contamination due to the extensive use of plastics in farming practices. This issue is further aggravated...

Effects of home-based isometric handgrip or aerobic training on blood pressure variability and vascular health in older adults with elevated blood pressure and hypertension: secondary results from The HoldAge Trial

Background Hypertension is a multifactorial condition that is likely to affect older adults. We evaluated the effects of home-based isometric handgrip training (IHT) or aerobic exercise training (AET) on vascular health of older adults with elevated blood pressure (BP) and hypert...

Exercise Training Characteristics and Psycho-Bio-Chemical Outcomes in Individuals with Addictive Behaviours: A Scoping Review

Addictive behaviours are associated with substantial neurobiological, psychological, and behavioural impairments. Exercise training has emerged as a potential complementary strategy in addiction treatment; however, the characteristics of exercise interventions and their associate...

A hybrid global maximum power point tracking of a PV-Battery system under complex partial shading conditions using horse herd optimization algorithm and a variable step size perturb and observe

Photovoltaic (PV) arrays are sensitive to variable environmental conditions, which requires continuous regulation to maximize power, this makes maximum power point (MPP) trackers an essential element in every PV generation system, in particular, when PV arrays are under nonunifor...