Instituto Nacional de Enfermedades Respiratorias

Effect of altitude on respiratory oscillometry in healthy adults

Respiratory oscillometry is a sensitive, non-invasive pulmonary function test that does not require forced breathing maneuvers. Although the density of the inspired gas is known to influence the measurement, its effect within the same subject at different altitudes has been littl...

Identification of venues for HIV prevention interventions through overlapping HIV transmission and venue elicitation networks

BACKGROUND: Understanding the role of physical venues in HIV transmission may be advantageous for targeting HIV prevention efforts, especially among groups experiencing high HIV incidence. SETTING: Large public clinic in Mexico City, Mexico. METHODS: We analyzed data from 7,502 p...

Characterization of plasma TNFRSF/TNFSF molecule profiles in HIV-associated disseminated Kaposi’s sarcoma over short- and long-term follow-up

The tumor necrosis factor superfamily (TNFSF) members regulate diverse cellular processes, yet their systemic profiles remain insufficiently characterized in persons living with HIV (PLHIV) with disseminated Kaposi sarcoma (DKS) caused by Kaposi’s sarcoma-associated herpesvirus (...

Clinicopathological factors potentially relevant to pulmonary intravascular fibrin organisation in patients with COVID-19: an autopsy-based study

Microvascular thrombosis is a hallmark of severe COVID-19, but the structural organisation of fibrin within these thrombotic formations remains poorly characterized. We previously identified a distinctive radial fibrin pattern in pulmonary and renal microvessels; however, factors...

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

Polycomb domains safeguard cell identity by maintaining lineage-specific chromatin states enriched in repressive histone modifications, preserving the epigenetic memory of cell lineages. While Polycomb repressive complex 2 (PRC2) can reestablish its occupancy after perturbation,...

Standardized Sechium edule root extract attenuates LPS inflammation alongside transient STAT3 phosphorylation and an interleukin 10 biased macrophage response

Chronic low-grade inflammation is sustained by macrophage activation toward proinflammatory states and contributes to cardiometabolic and degenerative disorders. Given the growing interest in evidence-based medicinal plants, we investigated whether a hydroalcoholic root extract o...

Association between preoperative malnutrition and hospital length of stay in adults with major lung resection: A prospective cohort study

BACKGROUND: Postoperative infections remain a frequent complication after lung resection, and malnutrition is highly prevalent in this population. However, evidence on the impact of malnutrition on clinical outcomes following major lung surgery is limited. This study evaluated th...

Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome

Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angiogenic and thromboinflammatory dysfunction, though long-term biomarker behavior remains unclear. To evaluate the evolution of angiogenic and thromboinflammator...