Instituto Nacional de Cardiología

Empagliflozin and Metformin Combination Therapy Attenuates Oxidative Stress and Inflammation in Experimental Cardio–Kidney–Metabolic Syndrome

This study evaluated the therapeutic effects of the empagliflozin+metformin (E+M) combination on cardio–kidney–metabolic syndrome (CKMS) using an experimental model. Animals were fed a Paigen-type (high-fat) diet supplemented with sugar-sweetened beverages to induce the CKMS phen...

A q-deformed deterministic gradient framework generalizing affine projection adaptive filters

Purpose This work proposes a q-deformed deterministic gradient framework that generalizes affine projection adaptive filters by embedding a deformation of the classical gradient operator into a fully deterministic formulation. Design/methodology/approach By embedding the q-gradie...

Dietary Patterns and the Social Development Index in Mexico City: A Machine-Learning Approach

Background: Dietary composition reflects the interplay of individual and contextual factors, yet its relationship with socioeconomic–territorial conditions remains insufficiently characterized in large Latin American cities. Methods: We identified empirical dietary patterns among...

Aloe-Emodin Modifies Adipogenic Genes and the Expression of miR-143 and miR-155 in 3T3-L1 Cells

Adipogenesis is crucial for maintaining energy homeostasis, as it facilitates the differentiation of mesenchymal stem cells into adipocytes. This process is transcriptionally regulated by key factors including PPARγ and C/EBPβ, alongside FABP4 during lipogenesis. However, it is n...

Premature Coronary Artery Disease, Association with Relative Blood Number of Mitochondrial DNA Copies in Mexican Population—Results of GEA Study

The mitochondrial DNA copy number (mtDNA-CN) is considered an indirect indicator of the number of mitochondria and of mitochondrial dysfunction; its decrease may indirectly reflect mitochondrial DNA (mtDNA) alterations. A reduction in mtDNA-CN is associated with the development o...

Exploring the Role of the SLC12A Cation-Coupled Chloride Cotransporters in the Cardiovascular System

Cardiomyopathies are a major category of cardiovascular disease, significantly contributing to global morbidity and mortality. Their pathogenesis involves a complex interplay of genetic and environmental factors, with multiple gene families playing critical roles in disease progr...

Integrating Kidney Imaging for Risk Prediction, Therapeutic Monitoring, and Prognostication Across the Kidney Disease Spectrum: A Review of Emerging Evidence

Abstract Kidney imaging advances are transforming the field of nephrology by allowing non-invasive examination of renal structure, function, and pathology. Traditional measures such as albuminuria and estimated glomerular filtration rate (eGFR) are only partially effective in ide...