Instituto Nacional de Câncer - INCA

Real-world performance of the breast GPA in breast cancer brain metastases in a resource limited setting

The Breast Graded Prognostic Assessment (B-GPA) is a validated prognostic score used to estimate survival in patients with breast cancer brain metastases (BCBM). However, real-world evidence assessing its prognostic accuracy, particularly in low- and middle-income countries (LMIC...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Prognostic factors associated with survival in patients with colorectal cancer treated with capecitabine: A cohort study

Introduction: Colorectal cancer is a major public health problem due to its high incidence and mortality rates worldwide. Various clinical and sociodemographic characteristics are intrinsically linked to this neoplasm and can have a significant influence on both survival estimate...

Real-world outcomes of CD34⁺ mobilization and early autologous hematopoietic stem cell transplantation recovery after daratumumab-based induction

INTRODUCTION: Daratumumab, an Anti-CD38 monoclonal antibody, is now widely used in frontline induction for transplant-eligible multiple myeloma. Although highly effective, concerns remain regarding its potential impact on CD34⁺ stem cell mobilization and early outcomes after auto...

Trop-2 overexpression as a prognostic marker in early triple-negative breast cancer: results from the GEICAM_CIBOMA trial

Trophoblast cell-surface antigen 2 (Trop-2) is a key therapeutic target in metastatic triple-negative breast cancer (TNBC), yet its prognostic significance in early-stage disease remains poorly defined. We evaluated Trop-2 expression and its clinical impact within a sub-cohort of...

Clinical presentation and outcomes according to KRAS status in advanced non-small cell lung cancer

The goal of the current study was to assess the frequency of KRAS mutation subtypes in a cohort of advanced non-small cell lung cancer (NSCLC). More importantly, we present the clinical characteristics, treatment profile, as well as overall survival (OS) according to KRAS mutatio...

Discontinuous Peripheral Punctate Echogenic Foci in Thyroid Nodules: A New Sonographic Pattern Suggestive of Papillary Carcinoma

Background: Ultrasound risk stratification systems for thyroid nodules worldwide describe different types of echogenic foci, including punctate echogenic foci (microcalcifications), coarse internal calcifications, and peripheral (rim) calcifications (complete or incomplete), with...

Intramedullary injection of polymerized laminin in acute traumatic spinal cord injury: a first-in-human pilot study

Abstract Study design Investigator-initiated, single-arm, first-in-human pilot study. Objectives To evaluate the safety and feasibility of intramedullary administration of polymerized laminin in individuals with acute complete spinal cord injury (SCI). Setting Public and private...