Instituto Evandro Chagas

Racial and Socioeconomic Inequities in COVID-19 In-Hospital Mortality in Brazil in the Post-Emergency Era: A National Cohort Study of 19,718 Hospitalized Adults in 2024

Abstract Background In 2024, COVID-19 entered a post-emergency phase, but in-hospital mortality remains a relevant public health concern in Brazil. As population immunity, vaccination, and clinical management evolved, the hierarchy of mortality predictors may have shifted from tr...

Optimizing the Production of a Condensed Tannin-Based Bioflocculant for Toxic Metal Remediation

Abstract Conventional water treatment typically employs chemical coagulants and flocculants, such as aluminum sulfate and iron salts. However, the intensive use of these products can lead to negative environmental impacts and pose significant health risks. In this context, bioflo...

Factors associated with tuberculosis-attributed mortality in the Brazilian Amazon: a population-based retrospective cohort study with survival and competing-risk analyses

Abstract Background Tuberculosis mortality remains a major public health challenge in the Brazilian Amazon, where clinical vulnerability, social inequities, and heterogeneous access to healthcare may contribute to poor outcomes. This study aimed to identify factors associated wit...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population

Post-COVID-19 syndrome (PCS) can persist even after mild acute illness, and oxidative stress has been proposed as a central mechanism for this persistence, although it remains poorly studied in the Amazon. This study characterized redox imbalance in patients with PCS through a co...

An in-depth comparison: first wave of mpox in Rio de Janeiro, Brazil and Lisbon, Portugal

Abstract Background The 2022 mpox outbreak spread rapidly beyond endemic regions, affecting multiple countries with broadly similar transmission patterns but different public health responses and surveillance systems. We compared laboratory-confirmed mpox infections reported duri...