Instituto Estadual do Cérebro Paulo Niemeyer

New and emerging pharmacological treatment options for acromegaly: a 2026 update

Introduction Acromegaly is associated with significant morbidity, impaired quality of life (QoL), and increased mortality when uncontrolled. While current treatments achieve biochemical control in many patients, a substantial proportion remain uncontrolled or experience persisten...

Timing of aneurysm repair and clinical outcomes after aneurysmal subarachnoid hemorrhage: a systematic review

BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) causes substantial morbidity and mortality, and guidelines recommend aneurysm repair as early as feasible. However, the association between onset-to-treatment time and outcomes remains uncertain. This review synthesized eviden...