Instituto do Sono

Circadian dysregulation of leptin and its role in skin inflammation and obesity: an integrative perspective

Abstract Purpose Leptin is an adipokine that regulates energy balance and is commonly linked to obesity. It exhibits a circadian rhythm that can be disrupted by variations in eating times and sleep disorders. This brief review explored how leptin can modulate appetite and tissue...

Could the use of melatonin be a promising complementary strategy in the prevention of skin cancer?

Abstract Skin cancer, including both non-melanoma and melanoma types, remains the most common neoplasm worldwide. Given its rising incidence, limitations of current therapies, and the challenges of effective prevention, novel therapeutic and preventive strategies are needed. One...