Institution
Instituto di Biofisica
Recent research
- BiologyOpen access
A GPRC5B–Fyn signaling axis regulates VRAC activity by targeting LRRC8A
The mechanisms by which physiological signals gate the volume-regulated anion channel (VRAC) remain poorly understood. Here, we identify a GPRC5B–Fyn signaling axis that directly controls VRAC activation by targeting the essential subunit LRRC8A. We found that the orphan G protei...
- Climate & EnvironmentOpen access
Response of the Carbonate System to Ocean Alkalinity Enhancement: A Mesocosm-Scale Experiment
Abstract We present the results of a mesocosm-scale experiment conducted in 2023 in the eastern Mediterranean Sea (Crete, Greece) to evaluate the effects of ocean liming via the addition of calcium hydroxide. We assessed two dosage regimes through repeated additions─low (20 μmol...
- BiologyOpen access
Abstract Volume-regulated anion channels (VRACs), formed by heteromers of LRRC8 subunits, mediate the transport of anions and organic osmolytes in numerous physiological processes. Although their gating mechanism remains poorly understood, conformational rearrangements of the cyt...
- Health & MedicineOpen access
Glycyrrhiza glabra is an herbaceous plant native to Eurasia, living in mild climates, and spread worldwide. Liquorice serves as a vital resource for human health, used as medicinal plants in feed and food, with anti-inflammatory and anticancer properties. To the best of our knowl...