Instituto de Química y Fisicoquímica Biológicas

Mannose-Functionalized Polymeric Micelles Target CD206-Expressing Macrophages Within Human Tuberculosis Granulomas and Improve Isoniazid Delivery

Background: Latent tuberculosis infection (LTBI) remains a global health challenge, in part due to the ability of Mycobacterium tuberculosis (Mtb) to persist within granulomatous lesions where drug exposure may be limited. Because granulomas are heterogeneous structures composed...

Mitochondrial Dysfunction Markers in Paediatric Obesity: DNA Content and Oxidation Damage

ABSTRACT Background Childhood obesity increases chronic disease risk. Mitochondrial dysfunction, reflected by altered mitochondrial DNA (mtDNA) content and oxidative damage, has been implicated in obesity‐related metabolic disorders, but paediatric data remain scarce. Objective T...

Porphyrin-Cross-Linked Unimolecular Polyglycerol Nanogels: Confinement-Controlled Metalation and Selective Cu2+ Detection

Abstract Unimolecular nanogels (NGs) based on (hyper)branched cyclic polyglycerols ((h)bcPGs) of two molecular weights (Mn = 8 and 60 kDa) were prepared through intramolecular cross-linking with the tetraboronic acid–functionalized porphyrin, 5,10,15,20-(tetra-4-dihydroxyborylphe...

Bacterial Communities Associated with Deschampsia antarctica in Chronically Diesel-Contaminated Soils: Candidate Taxa for Microbe-Assisted Phytoremediation

More than six decades of human activity in Antarctica resulted in chronic diesel contamination of soils surrounding research stations. Phytoremediation assisted by the native vascular plant Deschampsia antarctica is one of the few remediation strategies compatible with the Antarc...

Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release

. A long-standing question, however, has been whether these effects depend on iron delivery or instead reflect an intrinsic trophic property of the protein. To directly address this point, we used the oligodendroglial precursor cell line Oli-Neu and two previously characterized n...

Subchronic Cannabidiol (CBD) Treatment During the Silent Period Fails to Prevent Increased Seizure Susceptibility Following Lithium-Pilocarpine-Induced Status Epilepticus

Introduction. In recent years, cannabidiol (CBD) has been used as an adjunct therapy to anti-seizure medications for the control of seizures in patients with drug-resistant epilepsy. In addition to its anticonvulsant effect, CBD also has well-defined anti-inflammatory properties....