Instituto de Investigaciones Biomédicas Sols-Morreale

Cortical and metabolic brain development during pubertal hormone suppression

Suppression of pubertal hormonal signaling may alter trajectories of cortical development. However, the neurobiological effects of gonadotropin-releasing hormone agonists (GnRHa), including triptorelin, which are used in adolescents with gender dysphoria, remain largely unresolve...

Liver X receptor (LXR) signaling in macrophage inflammation and cardiometabolic disease.

Cardiometabolic diseases profoundly remodel tissue immune landscapes, characterized by the accumulation of diverse macrophage subtypes. Among these, lipid-associated macrophages (LAMs) have emerged as an important subset that is frequently observed in cardiometabolically affected...

Hypothyroidism Improves Survival in Experimental Peritonitis

Abstract Hypothyroidism decreases the basal metabolic rate. Using three models of peritonitis, intraperitoneal LPS plus Zymosan challenge, cecal slurry-induced intraperitoneal infection, and cecal ligation and puncture, we demonstrate that hypothyroid mice show enhanced survival...

Integrating genetics in the clinical care of patients with fibrotic interstitial lung diseases helps in diagnosis and predicting progression

Growing evidence suggests genetic basis in familial and other types of fibrotic interstitial lung disease (ILD). Genetics may improve diagnostic accuracy and risk stratification. The objective was to evaluate the utility of integrating genetic data into ILD clinical practice. A r...

INPP5E interactome reveals novel connections to growth factor signaling

Abstract Primary cilia are sensory cell membrane protrusions whose malfunction causes diseases known as ciliopathies. Joubert syndrome (JBTS) is a rare recessive ciliopathy causing brain malformations and kidney cysts, among other manifestations. A key player in JBTS is INPP5E, a...

Chemical Stabilizationand Transformation of SchiffBase Scaffold: A Path toward Superior Platinum-Based Anti-Cancer StemCell Drugs

Abstract The clinical application of platinum-based anticancer agents is limited by poor aqueous stability, low solubility, and dose-limiting toxicities. Here, we report two Pt(II) complexes based on a Schiff base ligand and its reduced imine derivative, designed to overcome thes...

A clinical and experimental investigation of liraglutide effects on the brain-kidney axis

Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before-and-after study and...