Instituto de Investigaciones Biomédicas Sols-Morreale

Chemical Stabilizationand Transformation of SchiffBase Scaffold: A Path toward Superior Platinum-Based Anti-Cancer StemCell Drugs

Abstract The clinical application of platinum-based anticancer agents is limited by poor aqueous stability, low solubility, and dose-limiting toxicities. Here, we report two Pt(II) complexes based on a Schiff base ligand and its reduced imine derivative, designed to overcome thes...

A clinical and experimental investigation of liraglutide effects on the brain-kidney axis

Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before-and-after study and...