Instituto de Investigaciones Biomédicas en Retrovirus y Sida

Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity

Abstract Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has evolved strategies to evade innate immunity and establish persistent infection. However, the mechanisms by which M. tuberculosis reprograms human macrophage metabolism remain incompletely defined....

HIV-1 diagnosis during pre-exposure prophylaxis: A case report

We report a case of HIV diagnosis in a 36-year-old man who has sex with men receiving daily oral PrEP (emtricitabine/tenofovir) in Argentina, where viral load or HIV PCR testing is not routinely available before or during prophylaxis. In 2022, PrEP was initiated after a diagnosis...

Angiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells

Abstract Mitochondrial homeostasis, governed by the balance between biogenesis and mitophagy, is essential for steroidogenesis in adrenocortical cells. While the requirement of active mitochondria for steroid synthesis is well-established, the hormonal regulation of genes governi...

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus–host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant...