Institution
Instituto de Investigación Sanitaria del Principado de Asturias
Recent research
- Health & Medicine
Genomic and clinical landscape of RAS mutations in acute myeloid leukemia
RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1...
- AI & ComputingOpen access
A Cox-Based Framework for Quantile Estimation
Quantile regression (QR) provides a flexible framework for characterizing conditional distributions and can offer useful insights for quantile estimation. In this paper, we provide intuition for the interpretation of QR by highlighting the approach that it is a reparameterization...
- Health & MedicineOpen access
The superficial musculoaponeurotic system (SMAS) is a fundamental concept in facial anatomy and surgery, but its organization within the human lips remains incompletely defined. This narrative review critically reassesses the anatomical evidence for a labial SMAS and its regional...
- Climate & EnvironmentOpen access
Diet quality and environmental sustainability: integrating dietary indices and planetary impacts
Dietary patterns are major determinants of nutritional status and environmental sustainability. Despite growing interest in sustainable diets, limited research has examined how dietary carbon footprints differ across age groups and how age-specific dietary behaviors interact with...
- Society & EconomicsOpen access
Background Patients receiving invasive mechanical ventilation (IMV) in the intensive care unit (ICU) experience significant physiological stress, which may impair recovery. Music intervention is a promising nonpharmacological strategy to modulate stress responses; however, eviden...
- Health & MedicineOpen access
Abstract Cellular senescence plays a pivotal role in aging and cancer, two major biomedical and socioeconomic challenges of our time. Therefore, its study has become crucial for the design of interventions based on its manipulation. In this sense, researchers have developed a wid...
- Health & Medicine
Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement
BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...
- Health & MedicineOpen access
Update on Perioperative Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Cardiac surgery-associated acute kidney injury (CS-AKI) increases short- and long-term mortality, progression to chronic kidney disease (CKD), and healthcare costs. Its pathogenesis is multifactorial—combining renal hypoperfusion, impaired oxygen delivery, hemodilution, inflammat...
- BiologyOpen access
A dual role for miR-210-3p in hypoxia-driven signaling and mitotic regulation in cancer
miR-210-3p is a well-established hypoxia-induced microRNA that is commonly upregulated in a wide range of solid tumors, traditionally linked to mitochondrial repression and hypoxia-inducible factor (HIF) signaling. However, its functional role in cancer remains complex and highly...
- Health & MedicineOpen access
The objective is to describe patterns of noncommunicable disease (NCD) service delivery and the operational roles of the different Emergency Medical Team (EMT) types-Type1 mobile (outpatient mobile primary care), Type1 fixed (outpatient static primary care), and Type2 (inpatient...
- Health & MedicineOpen access
Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening
BACKGROUND: Genetic testing (GT) is established in ambulatory cardiomyopathy (CM), but its utility after heart transplantation (HTx) recipients remains poorly characterized. OBJECTIVES: This study aimed to evaluate the clinical utility of GT in adult HTx recipients with CM, focus...