Instituto de Investigación Sanitaria de Santiago

Polymer Coating Adhesion Drives Functional and Biological Outcomes in Meniscus Implants

Achieving stable integration of drug-releasing polymer coatings with load-bearing meniscus implants remains a challenge in biomaterials engineering. In this study, four surface modification strategies, femtosecond-pulsed laser treatment, oxygen plasma, polydopamine, and an ethyl-...

The NBGENS project protocol: Pilot study for genetic newborn screening in Galicia

Background Conventional newborn screening (NBS) relies on mainly biochemical assays and remains limited by its dependence on detectable biomarkers within a narrow postnatal window, leaving many treatable genetic disorders unidentified. Advances in next-generation sequencing have...

Salivary biomarkers of inflammation, angiogenesis, and aging in hookah smokers, cigarette smokers, and non-smokers

Hookah smoking is an increasingly prevalent form of tobacco consumption, particularly among young adults. Although conventional cigarette smoking is well established as a modulator of inflammatory and biological processes in the oral environment, salivary inflammatory and protect...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Hypothyroidism Improves Survival in Experimental Peritonitis

Abstract Hypothyroidism decreases the basal metabolic rate. Using three models of peritonitis, intraperitoneal LPS plus Zymosan challenge, cecal slurry-induced intraperitoneal infection, and cecal ligation and puncture, we demonstrate that hypothyroid mice show enhanced survival...

Serum and ileocecal valve proteomic profiles associated with the multifocal pathological form of bovine paratuberculosis

Abstract Bovine paratuberculosis (PTB) lesions progress from focal to multifocal and diffuse pathological forms as infection advances. Whether multifocal lesions represent an intermediate stage in disease progression or a distinct disease outcome remains unclear. This study compa...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Ensuring pragmatic and equitable paths forward for hepatitis B virus infection eradication in Latin America

INTRODUCTION: Latin America occupies a paradoxical position in hepatitis B virus (HBV) elimination: aggregate prevalence is low, yet the region remains far from the WHO and PAHO 2030 targets because the burden is structurally concealed within underserved populations and fragmente...

Expanding CIRdb, a comprehensive catalog of whole-exome sequencing data of Canary Islanders.

) gene, which is associated with body mass index, cardiovascular health, and metabolic and respiratory traits. Taken together, our findings show that CIRdb presents a valuable resource of exome-wide genetic variation in a population at the edge of Southwestern European genetic di...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...

Eating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort

ABSTRACT Objective This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods We conducted a cross‐sectional an...

Weight regain after obesity treatment: mechanisms, predictors, and real-world evidence from the IGOBE program

Weight regain is the defining challenge of obesity treatment and remains insufficiently addressed in current clinical paradigms. Despite substantial initial weight loss achieved through lifestyle, pharmacological, or surgical interventions, most individuals experience partial or...

Circulating MMP-7 is associated with cognitive decline in individuals with vascular risk factors

Background Vascular risk factors contribute substantially to late-life cognitive impairment and interact with neurodegenerative processes underlying dementia. Blood–brain barrier (BBB) dysfunction has emerged as a key mechanism linking vascular pathology to cognitive decline; how...