Instituto de Investigación Marqués de Valdecilla

Impact of the 2023 ACR/EULAR classification criteria on thrombotic antiphospholipid syndrome: reclassification patterns and long-term outcomes in a 419-patient cohort

The 2023 ACR/EULAR classification criteria for antiphospholipid syndrome (APS) were developed to improve specificity and to define more homogeneous research populations. However, their performance in real-world cohorts of thrombotic APS with long-term hard outcomes remains insuff...

Humanized anti-BAMBI monoclonal antibody as a novel therapeutic strategy for psoriatic arthritis

Psoriasis (PsO) is a chronic autoimmune skin disease that affects 2% of the global population, with 30% of patients progressing to psoriatic arthritis (PsA). Both conditions are primarily mediated by CD4 + T cells, whose differentiation into distinct subpopulations depends on the...

Growth Differentiation Factor 15 Is Associated with Severe Coronary Artery Calcification in Patients with Chronic Kidney Disease

Patients with chronic kidney disease (CKD) have a high burden of coronary artery calcification (CAC) and cardiovascular risk. GDF-15 is a stress-responsive biomarker linked to kidney dysfunction and adverse cardiovascular outcomes, but its relationship with CAC across CKD stages...

PRECISE: Benchmarking digital pathology with expert-annotated contiguous IHC–H&E serial prostate sections

We present PRECISE (PRostate Expert-annotated Contiguous IHC–H&E Serial sEctions), a hybrid histopathology dataset of paired hematoxylin and eosin (H&E) and immunohistochemistry (IHC) whole-slide images (WSIs), comprising 37 prostate core needle biopsies from 25 patients, each wi...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Ultrasensitive serum levels of interleukin 13 in systemic lupus erythematosus patients: a cross-sectional study

Systemic lupus erythematosus (SLE) is characterized by elevated levels of various cytokines. Interleukin (IL)-13 is a pleiotropic type 2 cytokine that plays a central role in allergic inflammation and tissue fibrosis. Until recently, serum measurement of IL-13 was not feasible be...

Knowledge of the International Code of Marketing of Breast-milk Substitutes among maternal and child health professionals in Spain: a nationwide cross-sectional study

The International Code of Marketing of Breast-milk Substitutes protects breastfeeding by restricting inappropriate promotion. This study assessed knowledge, attitudes and perceived compliance with the Code among maternal and child health professionals in Spain. A nationwide cross...

Lifestyle and its relationship with health literacy, sense of coherence and sociodemographic factors in a Spanish primary care population: a multicenter cross-sectional study

Health behaviors are driven by a complex interplay of individual and structural factors. While health literacy and sense of coherence are widely studied as psychosocial enablers of healthy lifestyles, evidence comparing their impact against broader social determinants of health r...

Optimizing exercise for breast cancer survivors: a randomized controlled trial of daily individualization of high-intensity online concurrent training guided by autonomic modulation

Abstract Background Breast cancer and its treatments cause physical and physiological side effects that exercise can mitigate. However, there is little evidence on the effects and feasibility of high-intensity remote supervised training. In addition, there is no evidence of the e...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Characterization of Anisotropic Optical Behavior in Phase‐Change Material Sb 2 Se 3

ABSTRACT Phase‐change materials with ultralow optical losses are enabling a new generation of reconfigurable photonic devices. Sb 2 Se 3 has emerged as a leading candidate owing to its negligible optical losses across the visible and infrared, yet how polycrystallinity translates...

Association between risk of eating disorders and an unhealthy lifestyle score in university students: uniHcos project

Introduction The first year of university is a critical period for the consolidation of lifestyle habits and has been associated with an increased risk of developing eating disorders (EDs). This study aimed to assess the prevalence of ED risk among first-year Spanish university s...

Burden, perception of stigma, and gender differences among informal care partners of individuals with mild cognitive impairment

Background Caring for individuals with mild cognitive impairment (MCI) is increasingly recognized as a significant clinical challenge. However, the latent burden, driven by perceived stigma and gender-specific vulnerabilities, remains poorly characterized during these early stage...