Instituto de Investigación Biomédica de Málaga

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study

OBJECTIVE: Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox-...

Ebola-virus outbreaks are teleconnected with macroclimatic oscillations

Ebola viruses’ ecology is known to be affected by climate, which is globally monitored using macroclimatic oscillation indices. We tested whether any of 26 macroclimatic oscillation indices were teleconnected with Ebola virus disease (EBOD) outbreaks. We compiled an updated datab...

Responsiveness of the Stair Climb Test Across Follow‐Up Periods and Baseline Severity in Knee Osteoarthritis

ABSTRACT Background and Purpose The properties of the Stair Climb Test (SCT) remain to be determined in patients with knee osteoarthritis. Thus, this study aimed to evaluate the responsiveness and clinically meaningful improvement of the SCT across different follow‐up periods and...

Differential effects of acute, chronic, and social defeat stress on microglial morphology in the basolateral and central amygdala, and the medial and lateral habenula

Abstract Effective stress regulation is essential for emotional health, whereas maladaptive stress responses contribute to neuropsychiatric disorders such as depression and post-traumatic stress disorder. Because neuron–microglia interactions are increasingly recognized as key mo...

Whole-genome sequencing of Reed-Sternberg cells identifies outcome determinants in Hodgkin lymphoma

Abstract Classical Hodgkin lymphoma (cHL) is a B-cell-derived malignancy characterized by rare Hodgkin and Reed–Sternberg (HRS) cells within an extensive inflammatory microenvironment. Although most patients achieve durable remission with first-line therapy, a subset relapse or e...

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study in...

Advancing Physical Therapy: Integrating Biomechanics, Neuroscience, and Systemic Health

Physical therapy has undergone substantial evolution in recent decades, extending beyond post-surgical and post-traumatic rehabilitation to encompass prevention, health promotion, differential screening, and the management of complex movement-related conditions [...]

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug-induced liver injury (DILI) is still scarce. We aimed to ascertain the incidence, clinical profile, culprit drugs, and prognosis associated with concomitant DILI and AKI. We include patients from two long-...

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Gestational diabetes mellitus (GDM) increases offspring cardiometabolic risk, potentially through intrauterine epigenetic programming. We aimed to characterize GDM-associated DNA methylation differences in cord blood, evaluate their consistency with previously identified maternal...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Malnutrition Severity, Morphofunctional Assessment, and Survival in Patients with Lung Cancer: A Multicentre Prospective Cohort Study

PURPOSE: Malnutrition is common in lung cancer and may contribute to impaired functional status and poor survival. This study evaluated the association between GLIM-defined malnutrition, morphofunctional nutritional parameters, and one-year mortality in patients with lung cancer....

Proteo‐Metabolomic Profiling of PMM2 ‐ CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo ‐Inositol, and the Hexosamine Pathway

ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways,...

Proof-of-concept validation of p2GUS, a modular expression system for enhanced Ni-binding purification of functional recombinant proteins in Escherichia coli

Abstract Protein expression and purification remain critical steps in basic research, biotechnology, and industrial applications. Here, p2GUS, a modular Escherichia coli expression system generated through targeted modification of Precursor 1, a parental pBAD-derived vector, is d...

Short-term knowledge gains and learner satisfaction after a basic radiology course for family medicine residents in a 3-dimensional virtual environment: a multi-cohort pretest–posttest study in Spain

Purpose: This study aimed to evaluate a structured basic radiology course for Family Medicine residents delivered in a 3-dimensional (3D) virtual environment (Second Life). We hypothesized that participation would be associated with higher post-course knowledge test scores and hi...

Variables Associated with Prescription Opioid Misuse in Individuals with Chronic Noncancer Pain

OBJECTIVES: Current research highlights the importance of assessing the risk of opioid misuse in people with chronic noncancer pain (CNCP) before initiating treatment with these medications. Existing instruments to assess this risk demonstrate limited predictive capacity and lack...

Proteomic profiling of root microsomal membrane fractions reveals distinct RBOHC- and RBOHF-associated responses to cadmium in Arabidopsis

Cadmium (Cd) is a toxic heavy metal for plants, and although its mechanisms of toxicity are well characterized, the regulatory networks underlying plant responses remain incompletely understood. This study investigated membrane-associated molecular responses linked to RBOHC and R...

Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening

BACKGROUND: Genetic testing (GT) is established in ambulatory cardiomyopathy (CM), but its utility after heart transplantation (HTx) recipients remains poorly characterized. OBJECTIVES: This study aimed to evaluate the clinical utility of GT in adult HTx recipients with CM, focus...