Instituto de Investigación Biomédica de A Coruña

Cortical and metabolic brain development during pubertal hormone suppression

Suppression of pubertal hormonal signaling may alter trajectories of cortical development. However, the neurobiological effects of gonadotropin-releasing hormone agonists (GnRHa), including triptorelin, which are used in adolescents with gender dysphoria, remain largely unresolve...

Frailty in Older Adults: Pathogenesis, Treatment and Prevention

Abstract Purpose of Review Frailty is a geriatric syndrome of loss of reserves, characterized by multisystem dysregulations, limited capacity to maintain homeostasis, and increased vulnerability. This review is focused on the current knowledge on the main pathogenic mechanisms le...

UrbanFormAnalyzer: an open-source workflow to derive orientation-specific building envelope attributes from cadastral data

Detailed building-envelope information is essential for robust urban-scale energy performance analyses. However, national energy certificate databases in Spain and other countries often lack key attributes such as orientation-specific external perimeter measurements and glazing r...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Freshness flavour perception via quantum-inspired and quantum ligand-based virtual screening

Abstract Flavour perception is a complex and critical biological process in the food industry in general and in beer production in particular. Taste is influenced by the simultaneous interaction of a large number of molecules present in food and beverages with specific receptors...

Circulating MMP-7 is associated with cognitive decline in individuals with vascular risk factors

Background Vascular risk factors contribute substantially to late-life cognitive impairment and interact with neurodegenerative processes underlying dementia. Blood–brain barrier (BBB) dysfunction has emerged as a key mechanism linking vascular pathology to cognitive decline; how...

Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening

BACKGROUND: Genetic testing (GT) is established in ambulatory cardiomyopathy (CM), but its utility after heart transplantation (HTx) recipients remains poorly characterized. OBJECTIVES: This study aimed to evaluate the clinical utility of GT in adult HTx recipients with CM, focus...