Instituto Cajal

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Interictal electric source imaging with open‐source software and routine low‐density electroencephalography: A systematic comparison of four inverse methods in drug‐resistant epilepsy

Abstract Objective This study was undertaken to assess the diagnostic accuracy of interictal electrical source imaging (ESI) performed using open‐source software and routine low‐density electroencephalography (LD‐EEG), comparing four inverse methods at two spike time points. Meth...

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

Abstract Introduction The literature provides limited evidence on the effectiveness of psychological interventions for individuals living with Huntington’s Disease (HD). This study aims to examine the role of psychological support in improving the well-being of individuals and fa...

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study in...

Faunal Deposits in Pre-Beaker Funerary Contexts at Humanejos (Parla, Madrid, Spain)

This study presents the first zooarchaeological analysis of the faunal remains associated with the pre-Beaker funerary contexts of Humanejos (Parla, Madrid, Spain). A total of 3974 animal remains recovered from 31 burial pits were analysed. Species representation was assessed usi...

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune in...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Cost-effectiveness of lenacapavir versus tenofovir disoproxil fumarate plus emtricitabine for pre-exposure prophylaxis to prevent HIV-1 transmission in gay, bisexual, and other men who have sex with men in Spain

Background Lenacapavir (LEN), a twice-yearly subcutaneous capsid inhibitor, has demonstrated superior efficacy over daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) in clinical trials. No European cost-effectiveness analyses...

Return on investment in workplace health prevention and promotion: a systematic review (2003–2024)

Workplace health prevention and promotion (WHP) programs represent a strategic investment in human capital. Despite a growing body of evidence, synthesized economic evidence remains fragmented. This systematic review addresses identified gaps in the literature by synthesizing eco...