Institute of Virology of the Slovak Academy of Sciences

Microbiological safety assessment of canine adipose derived mesenchymal stem cell preparations reveal no detectable contamination

The experimental application of canine adipose-derived mesenchymal stem/stromal cells (cAD-MSC) has demonstrated excellent therapeutic potential in the treatment of a number of previously untreatable or difficult-to-treat diseases. However, the production of cAD-MSC for clinical...

Dynamic tRNA modification programs align codon usage with growth-phase-specific gene expression in Pseudomonas aeruginosa

Post-transcriptional transfer RNA (tRNA) modifications dynamically regulate translational capacity, yet whether the tRNA epitranscriptome is temporally coordinated with gene expression programs during bacterial growth remains unknown. Here, we combine time-resolved nanopore tRNA...

Field evaluation of microbial antagonists for control of root rot and improvement of spring wheat productivity in Kazakhstan

This field study evaluated the effects of microbial seed treatments on field emergence, plant growth, yield components, and root rot development in spring wheat under the agro-climatic conditions of southeastern Kazakhstan. Two spring wheat cultivars, Diva and E-1, were used to a...

SARS-CoV-2 and RSV external quality assessment on molecular detection and variant typing in European expert laboratories in 2025

ABSTRACT We herein report on the fourth SARS-CoV-2 wet-lab external quality assessment (EQA) and the second organized by the AURORAE consortium to assess the diagnostic capabilities of European expert public health laboratories. Diagnostic capabilities were investigated regarding...

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

OBJECTIVE: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (B...

Hepatitis-associated virus infections in Austrian equids: A survey of equids sampled across Austria

This study aimed to determine the (sero)prevalence of equine hepacivirus (EqHV), equine parvovirus-hepatitis (EqPV-H), equid hepatitis B virus (EqHBV) and hepatitis E virus (HEV), in equids across Austria and to identify associated risk factors. In a cross-sectional study conduct...

Hepatitis B and D burden in Uzbekistan: comprehensive analysis of seroprevalence and risk correlates from a countrywide study

Abstract Background Uzbekistan faces a substantial burden of hepatitis B and D virus (HBV and HDV) infections despite implementing universal hepatitis B vaccination in 1998. Regional variation in disease distribution and contemporary transmission dynamics remain inadequately char...

Development of a multi-species luciferase-based double-antigen ELISA for the detection of antibodies against influenza A virus H5 clade 2.3.4.4b

ABSTRACT The highly pathogenic avian influenza viruses of subtype H5N1 represent a major threat to animal and public health. The current panzootic with H5 clade 2.3.4.4b has caused numerous, widespread outbreaks in various domestic and wild avian species with high mortalities, ma...

Completion of the 5′ end of the porcine teschovirus genome reveals a functional S-segment and enables reverse genetics

Porcine teschoviruses (PTVs) are swine-specific picornaviruses associated with neurological and systemic disease, ranging from severe paralytic Teschen disease to milder forms of porcine encephalomyelitis, known as Talfan disease. Despite their global distribution and veterinary...