Institute of Research and Innovation Parc Tauli

Pediatric Infectious Encephalitis in Spain

BACKGROUND: Pediatric infectious encephalitis remains a significant cause of neurologic morbidity. Prompt antiviral treatment is recommended in patients with suspected herpes simplex virus (HSV) encephalitis. This study aimed to describe the epidemiology and outcomes of infectiou...

Mediolateral Joint Balance Assessment Is Reproducible Between Surgeons, Under No Standardized Varus–Valgus Stress, During Robot-Assisted Total Knee Arthroplasty

Objective: To evaluate inter-surgeon variability in mediolateral joint balance assessment during robotic-assisted total knee arthroplasty (TKA) using the robotic surgical assistant (ROSA) Knee System, and to determine whether such variability influences the surgical planning gene...

Invasive Bacterial Infections Other Than Escherichia coli and Streptococcus agalactiae in Febrile Infants Younger Than 90 Days

BACKGROUND: Invasive bacterial infections (IBIs) in febrile infants ≤90 days are mostly caused by Escherichia coli and Streptococcus agalactiae. However, data on IBIs caused by other pathogens remain limited. METHODS: We conducted a multicenter retrospective study of febrile infa...

Patient–ventilator asynchronies beyond the waveform

PURPOSE OF REVIEW: Patient-ventilator asynchrony is commonly treated as a technical mismatch requiring correction, although asynchronous breaths are not uniformly harmful and apparent synchrony may conceal injurious effort. This review summarizes evidence from the past 18 months...

Targeted DNA Sequencing Reveals Distinct Rare-Variant Profiles in Pulmonary Hypertension Associated with Chronic Lung Diseases

The mechanisms underlying the development and severity of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) remain poorly understood. To investigate the contribution of genetic factors, we performed targeted sequencing...

Upcoming novel treatments for hidradenitis suppurativa: An overview of the pipeline

Abstract Recent developments in hidradenitis suppurativa (HS) have focused on targeting key inflammatory pathways implicated in the pathogenesis of the disease, including interleukin (IL)‐17, IL‐1, tumour necrosis factor (TNF), Janus kinase (JAK) and tyrosine kinase 2 (TYK2) sign...

Three clinical and immunological phenotypes of systemic lupus erythematosus onset identified through clustering analysis: data from the RELES registry

Abstract Background Systemic lupus erythematosus (SLE) shows heterogeneous clinical expression at onset, complicating early characterisation and risk assessment. We aimed to identify SLE phenotypes emerging after diagnosis and assess their clinical relevance. Methods We analysed...

Microbiological Factors and Patient-Reported Outcomes of Exacerbation Burden in Pseudomonas aeruginosa-Colonised Bronchiectasis: A One-Year Prospective Study

Background: Exacerbations are key determinants of disease progression and impaired health-related quality of life (HRQoL) in non-cystic fibrosis bronchiectasis (BE). Despite the recognised association between Pseudomonas aeruginosa (PA) and worse outcomes, factors driving exacerb...

Early Identification of Children at Risk for Complicated Parapneumonic Pleural Effusion: Development of a Prediction Model

BACKGROUND: Parapneumonic pleural effusion (PPE) is a frequent complication of pediatric pneumonia. Some cases progress to complicated PPE (cPPE), which is associated with greater morbidity, longer treatment, and a higher likelihood of need for pleural drainage. Early identificat...

Efficacy and Safety of Oral Creatine Supplementation in Patients with Heart Failure: A PRISMA 2020 Systematic Review and Narrative Evidence Synthesis

Background: Oral creatine is biologically plausible as an adjunct in heart failure (HF), but its clinical efficacy and safety remain uncertain. Methods: We performed a PRISMA 2020 systematic review (PROSPERO CRD420261391605) of oral creatine supplementation in adults with HF. Ran...

A low-cost imaging platform for quantitative characterisation of scaffold surface macrotopography with potential application in craniofacial tissue engineering

Craniofacial bone regeneration is a demanding application of tissue engineering (TE) in which scaffold architecture—pore size, shape and spatial distribution—is a determinant of regenerative success, so that reliable geometric quality control is a prerequisite for translation. Co...

Expanding the Neurological Phenotype of ZTTK Syndrome: A Case of Recurrent Acute Confusional Migraine

Acute confusional migraine (ACM) is an uncommon pediatric migraine variant characterized by transient confusion and agitation, nonspecific electroencephalographic changes, and normal bloodwork and neuroimaging. We present the first case of ACM in a child with Zhu-Tokita-Takenouch...

Therapeutic management of axial spondyloarthritis: summary of 2024 update of the Spanish clinical practice guideline (ESPOGUIA)

Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease associated with significant morbidity and impaired quality of life. Rapid advances in diagnosis, monitoring, and especially treatment over the past decade have increased the complexity of axSpA management...