Institute of Political Science, Academia Sinica

Native Mass Spectrometry Reveals Ligand-Specific Conformational Heterogeneity of the β1-Adrenergic Receptor Using Nanobody Probes

Abstract G protein-coupled receptors (GPCRs) are central physiological signal transducers and represent a primary class of therapeutic targets. While emerging evidence highlights a critical link between ligand-induced receptor conformations and pharmacological outcomes, the struc...

Intrinsic Fermi Level Pinning and Reversible Depinning at Ultralow-Defect Epitaxial MoSe2/Au(111) Interfaces

Abstract Fermi level pinning (FLP) fundamentally limits contact engineering in two-dimensional semiconductors, yet its intrinsic origin remains obscured by the presence of interfacial disorder and defect-induced gap states. Although theoretical models attribute FLP to metal-induc...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

Hydrothermally Grown NiFe Layered Double Hydroxide on Hastelloy Fiber Paper for the Oxygen Evolution Reaction in Anion-Exchange Membrane Water Electrolysis

Abstract Hastelloy fiber paper (HAP) exhibits excellent corrosion resistance, electrical conductivity, and structural robustness; however, its application as a porous transport layer (PTL) in water electrolysis systems remains relatively underexplored. In this study, a highly act...

Block Copolymer-Stabilized Complex Emulsions for Flow-Injection Detection of Perfluorooctanoic Acid in Multiple-Well Flow Chips

Abstract Rapid, field-deployable screening methods are needed for per- and polyfluoroalkyl substances (PFAS), particularly in high-load and non-potable water streams. Here, we report a responsive complex-emulsion platform in which acid-reactive block copolymers (BCPs) stabilize h...

Magneto-Electronically Coupled Quasiparticle Statesin Monolayered MoS2 Driven by the Proximity Effect of UltrathinSmFeO3

Abstract The magnetic proximity effect (MPE) of magnetic substrates provides an effective route to manipulate spin/valley-dependent quasiparticles in two-dimensional transition-metal dichalcogenides (TMDs) without requiring large external magnetic fields. Herein, we demonstrate a...