Institute of Organic Synthesis

Bis-Pyrene-Appended Polyvinyl Chloride: Mechanosynthesis and Nitro-Explosive Detection

The remote detection of nitro compounds typically requires complex analytical procedures and expensive instrumentation, often resulting in prolonged analysis times. Fluorescence-based methods, which exploit the quenching of organic fluorophores in the presence of nitro analytes,...

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...

Cobalt Carbonyl as a Solid CO(g) Source for the Synthesis of Novel Coumarin Derivatives and Biaryl Ketones by Palladium‐Catalyzed Carbonylative Suzuki–Miyaura Reaction

We herein report an atom‐economical, facile, and efficient approach developed for synthesizing a variety of C‐7 carbonylated coumarin derivatives and biaryl ketones in good‐to‐excellent yields. The use of aryl fluorosulfates as an atom‐economical electrophilic coupling partner an...