Institute of Organic Synthesis

Cobalt Carbonyl as a Solid CO(g) Source for the Synthesis of Novel Coumarin Derivatives and Biaryl Ketones by Palladium‐Catalyzed Carbonylative Suzuki–Miyaura Reaction

We herein report an atom‐economical, facile, and efficient approach developed for synthesizing a variety of C‐7 carbonylated coumarin derivatives and biaryl ketones in good‐to‐excellent yields. The use of aryl fluorosulfates as an atom‐economical electrophilic coupling partner an...

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...