Institute of Organic Chemistry

Preferential antiproliferative activity of an oleandrigenin-derived androstane toward prostate cancer cells

Abstract Cardiac glycosides, traditionally used for heart failure, are increasingly recognized for their anticancer potential. This study evaluated the in vitro antitumor activity of ten cardiac glycoside derivatives on androgen-insensitive (DU-145) and androgen-sensitive (LNCaP)...

Predicting Reactivity and Enantioselectivity from Small Experimental Datasets: A Case Study in Asymmetric Magnesium Catalysis

Abstract Predicting reactivity and enantioselectivity from limited experimental data remains a central challenge in asymmetric catalysis, where reaction development is often guided by small, internally generated scope datasets rather than large screening campaigns. Here, we show...