Institute of Organic Chemistry

Supramolecular Umpolung via Esterification: Converting Electron-Rich Phenolic Macrocycles into CH-Bonding Anion Receptors and Transporters

Abstract CH-bonding anion receptors are supramolecular hosts that combine high chemical robustness, reduced propensity for deprotonation, and distinctive selectivity patterns, which make them attractive for transmembrane transport and medicinal applications. Their broader use is,...

Resolving pulsed electric field effects on proteins in bulk aqueous solution

Externally applied macroscopic electric fields can couple to protein charge distributions and potentially alter protein conformation and function. Whether they produce persistent changes in bulk aqueous protein solutions remains unresolved because electrode-based field delivery c...

Perspectives on tissue-selective insulin derivatives

Insulin is a central regulator of metabolic homoeostasis with diverse, tissue-specific actions across multiple organs. Despite major advances in insulin formulations, current therapies rely on systemic delivery and do not reproduce the physiological distribution of endogenous ins...

Preferential antiproliferative activity of an oleandrigenin-derived androstane toward prostate cancer cells

Abstract Cardiac glycosides, traditionally used for heart failure, are increasingly recognized for their anticancer potential. This study evaluated the in vitro antitumor activity of ten cardiac glycoside derivatives on androgen-insensitive (DU-145) and androgen-sensitive (LNCaP)...

Predicting Reactivity and Enantioselectivity from Small Experimental Datasets: A Case Study in Asymmetric Magnesium Catalysis

Abstract Predicting reactivity and enantioselectivity from limited experimental data remains a central challenge in asymmetric catalysis, where reaction development is often guided by small, internally generated scope datasets rather than large screening campaigns. Here, we show...