Institute of Oncology Prof. Dr. Ion Chiricuta

Vascular Phenotyping Across the CKM Syndrome: Arterial Stiffness and Endothelial Function Testing, Prognostic Value and Clinical Implementation

Cardiovascular–kidney–metabolic (CKM) syndrome represents a continuum of metabolic, renal, and cardiovascular abnormalities in which vascular dysfunction may develop before clinically overt cardiovascular disease. Endothelial dysfunction, arterial stiffness, microvascular abnorma...

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

Somatic Blood Mosaicism and Psychiatric Disease: Current Evidence and Causal Limits

Somatic blood mosaicism is an established feature of ageing and a heterogeneous marker of haematologic cancer and inflammatory and vascular risk, but its psychiatric evidence base remains small. This structured critical narrative review evaluates mutation-defined clonal haematopo...

The Epigenetic Architecture of Classical Hodgkin Lymphoma: Lineage Erasure, Immune Escape, and Therapeutic Reprogramming

Classical Hodgkin lymphoma (cHL) is distinguished by a rare population of Hodgkin and Reed–Sternberg (HRS) cells that has largely extinguished its germinal center (GC) B-cell identity while maintaining survival, immune escape, and dependence on a highly organized tumor microenvir...