Institute of Neurobiology

Free fatty acid receptor 4 agonism stimulates insulin secretion via different mechanisms in mouse versus human islets

Abstract Activation of the free fatty acid receptor FFAR4 in pancreatic islets potentiates insulin and inhibits somatostatin (SST) secretion. Here we investigated the relative roles of δ and β cells in the insulinotropic effect of FFAR4 activation in mouse and human islets. The e...