Institute of Molecular Medicine

Minimal-length CAG repeats in AR define a hyperactive AR–LSD1 axis driving metabolic reprogramming in prostate cancer

The polymorphic CAG trinucleotide repeat in the androgen receptor ( AR ) gene encodes a variable-length N-terminal polyglutamine (polyQ) tract that modulates AR transcriptional activity, with shorter tracts generally enhancing AR activity. While the majority of men harbor CAG rep...

‘No, it is a virus, your body will fight it.’ The value of diagnostic testing for managing respiratory viruses in primary care: an observational study from a post-COVID pilot programme

Introduction International studies suggest that advancing diagnostic technologies have the potential to reduce uncertainty and improve management of acute respiratory infections. Aim This study aimed to observe the impact that laboratory-based polymerase chain reaction testing fo...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...