Institute of Molecular and Clinical Ophthalmology Basel

Autologous hematopoietic stem cell transplantation stabilizes retinal atrophy in multiple sclerosis

Abstract Autologous hematopoietic stem cell transplantation (aHSCT) is an effective treatment for aggressive multiple sclerosis refractory to disease-modifying therapies. Yet, its impact on neurodegeneration remains underexplored, and few predictive biomarkers for clinical outcom...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...