Institution
Institute of Microbial Technology
Recent research
- BiologyOpen access
TRIM62 facilitates influenza A virus entry by regulating WASH-dependent endosomal trafficking
Abstract Endocytosis enables efficient cargo uptake while restricting uncontrolled cellular entry, yet how this balance is enforced during endocytic uptake remains poorly understood. Using influenza A virus (IAV) as a model cargo, we reveal a previously unrecognized role for the...
- Health & MedicineOpen access
Dopamine alters macrophage metabolism promoting intracellular Mycobacterium tuberculosis survival
Dopamine (DA) is thought to aggravate progress of bacterial infections and enhance risk of intracellular bacterial infection like tuberculosis (TB). Though TB patients are known to present with high dopamine levels the causal link between them has remained unexplored. Mycobacteri...
- Health & MedicineOpen access
Visceral leishmaniasis (VL), a life-threatening parasitic disease caused by Leishmania donovani (LD), progresses primarily due to profound immunosuppression. However, the molecular and cellular mechanisms underlying this immune dysfunction remain poorly defined. In this study, we...
- Engineering & TechnologyOpen access
Aggregicoccus is a myxobacterial genus inherently deficient in fruiting genes
ABSTRACT Myxobacteria are fascinating and important prokaryotes with remarkable multicellular behaviors, which make them a model system for studying prokaryotic development and cooperation. Although there have been sporadic discoveries of myxobacterial species unable to fruit, it...
- Biology
Abstract Clinically approved therapies have established that combining β-lactam antibiotics with β-lactamase inhibitors is an effective strategy to counter antibiotic resistance; however, infections caused by metallo-β-lactamase (MBL) producing bacteria remain a critical unmet me...