Institute of Medical Sciences and Sum Hospital

Bridging the Gaps: Research Priorities and Policy Directions for Tribal Health in Odisha

Abstract Background: Building on the tribe-specific epidemiological data provided by the Odisha Tribal Family Health Survey (OTFHS), the present study employed a priority-setting approach to identify health challenges, research priorities, and actionable strategies for tribal hea...

Delivery room skin-to-skin contact for preterm neonates: a systematic review and meta-analysis

Abstract Background Immediate skin-to-skin contact (SSC) is the biological norm for newborns; however, preterm infants are routinely separated from their mothers at birth because of fears of thermal and clinical instability. This practice prioritizes technical stabilization and p...

Comparative Outcome Study of Transfacetal Fixation and Lateral Mass Fixation with Laminectomy in Subaxial Cervical Degenerative Compressive Myelopathy

Abstract Cervical spondylotic myelopathy is a chronic, progressive degenerative disorder of the spine that results in gradual deterioration of motor, sensory, and autonomic functions. Degeneration is the most common cause associated with myelopathy. Surgical intervention is dicta...

NRF2‐Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities

ABSTRACT Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron‐dependent form of regulated cell death driven by lipid peroxidation, has emerged...

Translation, cultural adaptation, and psychometric evaluation of the Odia version of QOL-AD: evidence from participants with dementia and caregivers

Dementia is a leading cause of disability and dependency among older adults, making quality of life (QoL) an important outcome of dementia care. However, no validated Odia version of the Quality of Life–Alzheimer’s Disease (QOL-AD) scale exists. This study aimed to translate and...

Dual-functional Er3+-doped Ca₂SiO₄: Enhanced dopamine sensing and high-resolution latent fingerprint visualization

Dopamine (DA) detection is crucial for the assessment of various metabolic and neurological disorders, and electrochemical biosensors have been widely investigated because of their high sensitivity, rapid response, and analytical accuracy. In this work, a novel sensing platform w...

Comparative genomics reveals genotype-phenotype concordance and cryptic resistomes in clinical Pseudomonas aeruginosa

Abstract Background Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen because of its adaptability. It shows rapid evolution of multidrug resistance (MDR). Phenotype-based diagnostics often fail to detect silent resistance determinants and early adaptive changes. This stu...

Dual primary malignancies are no longer a rarity: A single centre experience from eastern India

Objectives: Advancements in cancer therapies have improved long-term survival rates, contributing to an increased incidence of second primary malignancies. This study aims to describe the clinical characteristics, tumour profiles, and treatment patterns of patients diagnosed with...

Parasitic Masquerader: Hepatic Larva Migrans Presenting as Microabscess-Like Lesions

Abstract Hepatic visceral larva migrans (VLM) is an uncommon zoonosis that develops when second-stage nematode larvae migrate from the gut into solid viscera. It is most commonly caused by Toxocara species, the ascarid of dogs and cats. Clinically, it presents as an infective/inf...

Molecular screening of extended-spectrum β-lactamase and carbapenemase resistance genes in hospital wastewater from Eastern Odisha: Predominance of extended-spectrum β-lactamase determinants and absence of blaNDM and blaKPC

Objectives: The objective of the study is to determine the prevalence of antibiotic-resistant bacteria and characterize major ESBL and carbapenemase resistance genes in HWW from Bhubaneswar, Odisha, India. Materials and Methods: Wastewater samples were collected quarterly from si...

Outcomes of ABO ‐Incompatible Versus ABO ‐Compatible Liver Transplantation in Pediatric Recipients: An Updated Systematic Review and Meta‐Analysis

BACKGROUND AND OBJECTIVE: ABO-incompatible (ABO-i) liver transplantation (LT) in children is increasingly used to address organ scarcity, but concerns about immunological, vascular, and biliary complications remain. With evolving desensitization strategies and emerging pediatric...

The Transformation of the Microenvironment: From Observer to Coordinator in Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma Development

ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is a common asymptomatic plasma cell disorder and the major precursor state of multiple myeloma (MM). Although progression is partly shaped by intrinsic genetic and epigenetic changes within the plasma cell clone,...

Comparison of Clinical Characteristics and Outcomes of Systemic Lupus Erythematosus-associated Thrombotic Thrombocytopenic Purpura and Idiopathic Thrombotic Thrombocytopenic Purpura: A Single Centre Study from Eastern India

Objective: To investigate the clinical characteristics and outcomes of thrombotic thrombocytopenic purpura (TTP) in patients with systemic lupus erythematosus (SLE) compared to idiopathic TTP (I-TTP). Methods: This retrospective cohort study included adult patients with SLE-TTP (...