Institute of Infectious Disease and Molecular Medicine

Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections

The two parallel antibody-mediated prevention (AMP) efficacy trials evaluated whether intravenous infusion of the anti-CD4 binding site broadly neutralizing antibody VRC01 prevents HIV-1 acquisition. Here, we analyzed HIV-1 acquisition in AMP through the week 104 final study visi...

Decision-Linked Multimodal Prediction in Non-Metastatic Rectal Adenocarcinoma

Treatment options for non-metastatic rectal adenocarcinoma include total neoadjuvant therapy, selective radiotherapy omission, watch-and-wait, and mismatch-repair-guided immunotherapy. Prediction studies often conflate pathological and clinical complete response, radiological reg...