Institute of Immunology and Physiology

The I130V and S229F Tropomyosin Mutations Associated With Congenital Heart Disease Disrupt Actin‐Myosin Interactions in the Atria

ABSTRACT Tropomyosin is a highly conserved α‐helical coiled‐coil protein that is involved in maintaining the structural integrity of the sarcomere and regulating contraction of striated muscle. Mutations in the TPM1 gene encoding cardiac α‐tropomyosin (Tpm1.1) are associated with...