Institute of Himalayan Bioresource Technology

Multiscale Computational Insights into Bergenin Encapsulation by Modified γ-Cyclodextrins: Conformational and Energetic Investigations via QM/MM and Molecular Dynamics

Despite bergenin (BER) having significant therapeutic benefits, its medicinal potential is hindered by its low natural abundance and poor aqueous solubility. Through host-guest complexation with cyclodextrins (CDs), this work offers an economical molecular approach to increase th...

Unravelling the roles of redox homeostasis and antioxidant system in facilitating adaptive responses during Pb induced hormesis in Brassica juncea

Abstract This research explores the role of the antioxidant-prooxidant balance in eliciting the hormesis effect in Brassica juncea seedlings exposed to mild Lead (Pb). Excessive Pb doses in plants causes oxidative stress, which damages plant cells, stunts growth, and reduces agri...

Phloem protein 2 (PP2) regulates phloem-based defense against apple scar skin viroid and cucumber mosaic virus

The phloem protein 2 (PP2), one of the major phloem proteins, is known to be involved in the transport of nutrients, RNA, and defense; however, the molecular basis of its RNA-binding activity and its role in antiviral defense remain poorly understood. In the present study, we inv...

Reprogramming the Tumor Microenvironment and Cancer Therapy via Nanocatalytic Medicine

Abstract Cancer is one of the leading global health crises in the 21st century, accounting for nearly one in six deaths worldwide. Conventional treatment modalities, including surgery, chemotherapy, radiotherapy, and immunotherapy, remain insufficient and are frequently sabotaged...

Efficient in-vitro regeneration and transformation for CRISPR/Cas9-mediated genome editing of phytoene desaturase (PDS) gene in pea (Pisum sativum L.)

Key message The present study addresses optimization of in-vitro regeneration via direct organogenesis and Agrobacterium-mediated genetic transformation, enabling efficient multiplex CRISPR/Cas9-based genome editing of the phytoene desaturase (PsPDS) gene in pea. Abstract Pea (Pi...