Institute of Crystallography

Porphyrin−Peptide Bioconjugates: Photophysical Properties and Targeted Singlet Oxygen-Mediated Photooxidation of Amyloid-β

Abstract The aberrant self-assembly of amyloid β (Aβ) peptides into toxic oligomers is a central event in Alzheimer’s disease, motivating the development of molecular systems capable of modulating or degrading these species. Porphyrins and porphyrin−peptide bioconjugates have eme...

N-Adamantyl-1-Pentyl-4-Oxo-1,4-Dihydroquinoline-3-Carboxamide and N-(Adamantan-1-Yl)-2-(Alkyloxy)benzamide Derivatives as Fluorescent Probes for Selective CB2R Targeting

Background/Objectives: The cannabinoid receptor subtype 2 (CB2R) is an increasingly important therapeutic and diagnostic target because of its involvement in inflammation-associated disorders, including cancer and neurodegenerative diseases. CB2R biology has traditionally been in...

Water-Triggered Structural Transformation of a Hybrid Manganese Bromide for Visual Trace-Water Detection

Abstract Accurate detection of trace water is essential for ensuring the quality control of moisture-sensitive solvents, chemical processes, and advanced materials. Herein we present a water-triggered structural transformation in hybrid manganese bromide of MnBr2(C3H7NO) for visu...

Plant-mediated fabrication of Ag/TiO₂ bimetallic nanoparticles with anti-diabetic and anti-Inflammatory activities: Computational and experimental investigation

Globally, diabetes affects 589 million people and is a severe health epidemic, especially in regions where its incidence remains rising. The main challenge is the increase in diabetic complications and antibiotic resistance linked to conventional treatments. Bi-metallic nanoparti...

Design, synthesis, and biological evaluation of a dichloro-substituted schiff base as an α-amylase inhibitor: structural, computational, and molecular dynamics, in-silico approaches

Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistently high blood glucose levels. The emergence of drug resistance in DM therapy presents significant clinical challenges, highlighting the need for the development of new and effective therapeutic age...