Institute of Clinical Research

Circulating biomarkers in the diagnosis and management of neuroendocrine neoplasms

Abstract Neuroendocrine neoplasms (NENs) comprise a broad family of tumours arising from the diffuse neuroendocrine system and endocrine glands, and vary widely in clinical behaviour ranging from indolent to highly aggressive. Established monoanalyte biomarkers including chromogr...

Sustained Ventricular Tachycardia as the First Presentation of Hereditary Transthyretin Amyloidosis With the Glu109Gln Mutation

Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) most commonly presents with heart failure symptoms. Sustained ventricular tachycardia (VT) is an uncommon initial manifestation. Case Summary: A 57-year-old man presented with hemodynamically unstable monomorphic VT requi...

MemTrax as a scalable digital triage tool for mild cognitive impairment screening: primary validation in Alzheimer’s disease and exploratory analysis in Parkinson’s disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) pose escalating global health challenges, with early detection of mild cognitive impairment (MCI) being critical for timely intervention. The 2023 Delphi consensus highlights the need for scalable tools suitable for primary ca...