Institute of Chemical Biology and Fundamental Medicine

Randomization of the Damaged Base-Capping Loop Rewires Substrate Specificity in Formamidopyrimidine–DNA Glycosylase

Abstract Formamidopyrimidine–DNA glycosylase (Fpg) is a bacterial base excision repair enzyme that removes 8-oxoguanine (8-oxoG) and some other oxidatively damaged nucleobases from DNA. Fpg hydrolyzes the N-glycosidic bond of the damaged nucleotide and nicks DNA at the resulting...

Exploring the Potential of Phosphoramide N -Benzimidazole Oligonucleotides (PABAOs) as Antisense Agents

Abstract This study provides the first assessment of the therapeutic potential of phosphoramide benzoazole oligonucleotides (PABAOs) bearing N-benzimidazole moieties. Two series of antisense oligonucleotides (ASOs) targeting distinct regions of enhanced green fluorescent protein...

Circulating anti-Ro/SSA-antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis

Abstract Backgrounds Accumulating evidence indicates that anti-Ro/Sjögren’s syndrome-related antigen A(SSA)-antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval(QTc) prolongation by inhibiting the hERG-K+ channel. However, the numero...