Institute of Biomedical Science

Wavelength dependent effects of red and infrared photobiomodulation on neuropathic pain, skeletal muscle integrity, and mitochondrial respiration

Abstract Neuropathic pain is a chronic and difficult to treat condition affecting up to 10% of the population, significantly impairing quality of life and representing a public health concern. Photobiomodulation (PBMT) has emerged as a promising therapeutic approach, as photons c...

Integrated genomic and experimental assessment of the biosafety of Paraburkholderia sacchari as a promising microbial chassis

Abstract Paraburkholderia sacchari is an environmental member of the Burkholderiaceae with recognized biotechnological potential, yet its genomic diversity, biosafety profile, and evolutionary relationship to pathogenic Burkholderia species remain poorly understood. Here, we pres...

Evaluation of animal blood sources to enable Group A Streptococcus culture detection in low-resource settings

Preventative measures are urgently required to reduce the burden of group A Streptococcus (GAS) and its complications, especially in low- and middle-income and remote settings. Diagnostic identification of GAS from the oropharynx and skin involves growth of swab cultures on blood...

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human...

Beyond Tumor-Intrinsic STAT3: Integrating Metabolic and Immune Communication in the Tumor Microenvironment of Cervical, Ovarian, and Endometrial Cancers

Cervical, ovarian, and endometrial cancers comprise biologically distinct malignancies with substantial heterogeneity in their molecular alterations, metabolic dependencies, immune landscapes, and therapeutic responses. Despite advances in surgery, chemotherapy, radiotherapy, tar...

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

Abstract The parasympathetic efferent innervation to the respiratory airways controls bronchoconstriction and mucus secretion. It is known that the parasympathetic respiratory motoneurones (PRMNs) projecting to the airways are located in the nucleus ambiguus (NA) and dorsal motor...

Integrated Genome Mining and Bioactivity-Guided Isolation of Antimicrobial Peptides from Bacillus amyloliquefaciens BS4

Bacterial resistance remains a critical global health challenge, driving the continuous search for novel antimicrobial agents. Bacillus amyloliquefaciens is a recognized repository of bioactive metabolites; however, its full biosynthetic potential requires integrated genomic and...

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment

Plastic pollution has emerged as a global environmental and public health crisis, with micro- and nanoplastics (MNPs) representing a pervasive component of the human exposome. Generated through the continuous fragmentation of larger plastic materials, MNPs exhibit physicochemical...

Extended dispensing intervals for pancreatic enzyme extract without access destabilisation: a national retrospective study evaluating supply resilience during policy changes and medicine shortages in Australia

OBJECTIVE: This study aims to describe national trends in pancreatic enzyme replacement therapy (PERT) dispensing in Australia and assess changes following the introduction of 60-day prescription dispensing, in the context of medicine shortages and market changes. METHODS: Public...

Pressure-Gradient Identities for Material Deformation in Incompressible Euler Flow: A Staged Derivation of Affinity Defects, Pair Separation, and a Spherical Mean Law

This paper studies a specific question in incompressible Euler flow: what happens to material particle motion when the local deformation is not exactly affine? I do not present this as a solution to the Euler regularity problem, and I do not claim to build a new turbulence model....

Common pathways and outliers in glucose catabolism across Trypanosomatidae

Glucose catabolism in trypanosomatids differs significantly from that in most other eukaryotes. Here, the first few enzymes of the pathway are all located inside glycosomes, that is, the peroxisome‐like microbodies uniquely present in the Kinetoplastida and Diplonemida of the Eug...