Institute of Biomedical Chemistry

Protein Variability Patterns in Ovarian Serous Carcinoma

Protein variability patterns in cancer reflects both technical variation and biological heterogeneity and may provide information beyond mean abundance changes. We analyzed protein-level coefficients of variation across four ovarian cancer proteomic datasets, comparing controls a...

Cheminformatic identification of small molecules targeting acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis and high relapse rates when treated with cytotoxic chemotherapeutics. Previously, we identified a family of small molecules that modulate mitochondrial function, referred to as PS1...