Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

Noninvasive ultrashort wave neuromodulation enhances glymphatic clearance to alleviate traumatic brain edema and Alzheimer’s pathology

The glymphatic system clears cerebral waste, yet strategies to enhance its function remain elusive. Here, we show that 40.68 MHz ultrashort wave (USW) rapidly enhances glymphatic bulk flow in healthy mice within 10 minutes. USW potentiates both glymphatic influx and efflux, conco...

Demoted CD4+ T-cell activity resulted from CTNNB1 mutations resists lenvatinib plus anti-PD1 in HCC

Abstract Hepatocellular carcinoma (HCC) patients frequently fail to respond to combined anti-PD1 immunotherapy, though pre-existing neoantigen-specific CD8⁺ T cells within tumor microenvironment are reinvigorated upon PD1 blockaded. Tumor-intrinsic mechanisms driving the therapeu...

The impact of sleep quality on cognitive function in residents of high altitude areas: a cross-sectional study

This study aims to explore the current status of cognitive function among community residents in high-altitude areas, and analyze the influence of sleep quality on cognitive function, so as to provide a theoretical basis for developing intervention strategies to improve the cogni...

ipRGC-sensitive blue light exposure combined with exercise alleviates cognitive disorders and reverses pathological oscillations in mice

Non-pharmacological interventions including ipRGC-sensitive flickering blue light and physical exercise exert beneficial effects on cognitive function. However, whether their combined application confers additional benefits within a short intervention window where single interven...

Smoking status and duration are associated with taxonomic and functional differences in the oral microbiome

Smoking is a major modifiable risk factor for human health and has been linked to alterations in the oral microbiome. However, how oral microbial composition and functional potential differ across smoking duration remains insufficiently characterized. This study aimed to evaluate...

Enhancing FAIR data practices in China: An integrated strategy for biomedical research

The construction of scientific data compliant with FAIR (Findability, Accessibility, Interoperability, and Reusability) principles has become a consensus in the biomedical field. However, FAIR is often implemented at the data submission stage, leading to suboptimal outcomes, such...

Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo

Recording and real-time imaging of promoter activities are critical for deciphering signaling cross-talk, but technologies for simultaneously capturing multiple transient events in living cells are lacking. Here, we design fluorescent protein–based ticker tapes (FPTT) for multipl...