Institute for Systems Biology

Implementation of an Internalized Hemolysis Assessment Approach in Targeted Bottom-Up Proteomics for the Purpose of Blood Plasma Sample Quality Control

Abstract Mishandling of samples during blood plasma preparation may lead to biases in proteomic analysis and misinterpretation of data. An earlier study by Geyer et al. (2019) described proteins that may indicate poor plasma sample quality. Following this work, we have imitated a...

Activation of transposable elements is linked to a region- and cell type–specific interferon response in Parkinson’s disease

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammation, but their potential role in PD remains unexplored. Using bulk- and single-nuc...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...