Institute for Respiratory Health

The PASE Study: The Prevalence and Associations of Bendopnoea in Patients with Pneumothorax

Background: We recently established that bendopnoea (breathlessness upon bending forward) is common with pleural effusion; however, it has never been reported or investigated in patients with pneumothorax. This exploratory study investigated the prevalence and clinical relevance...

Identification of immunodominant ERV peptides critical for anti-metastatic immunity in a model of TNBC

Abstract The integration of immunotherapy into neoadjuvant treatment for triple-negative breast cancer (TNBC) has improved outcomes in some patients. Pre-clinical investigation of immunotherapy resistance in the aggressive 4T1 TNBC model has been hampered by a lack of known tumou...

Changes in cardiac function before and after hot water immersion and endurance exercise in middle-aged individuals with overweight or obesity

Abstract Purpose We investigated the acute effects of ecologically valid hot water immersion (HWI) and endurance exercise (END) interventions on indices of left (LV) and right ventricular (RV) function in middle-aged individuals with overweight or obesity. Methods Twenty-five (15...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Prevalence of psychological distress among family caregivers of children with cancer: a systematic review and meta-analysis

Abstract Purpose: This study aimed to systematically review and quantify the prevalence of anxiety and depressive symptoms in family caregivers of children with cancer and to explore potential determinants that may influence these outcomes. Methods: This systematic review and met...

Acute viral infection accelerates neurodegeneration in a mouse model of ALS

Summary While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated the impact of common, acute viral infections prior to disease on...

The pharmacogGENEtics in Youth Depression (GENE-YD) study for personalizing antidepressant pharmacotherapy for young Western Australians – A feasibility study

Abstract Pharmacogenetic (PGx) testing to guide antidepressant prescribing is becoming increasingly available. However, its uptake into routine psychiatric practice for young people remains limited due to insufficient youth-specific evidence and uncertainty regarding optimal tria...