Institute for Research in Biomedicine

NHEJ-mediated DNA synapsis and RPA-driven MRX exonuclease balance DNA end resection to control DSB repair

Abstract DNA double-strand breaks (DSBs) are repaired by Ku-dependent non-homologous end-joining (NHEJ) or DNA end resection-dependent homologous recombination (HR). Previously, it was shown that short-range resection by MRX-pSae2 can remove Ku from DSBs and initiate resection, s...

A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration

Genome-wide association studies investigating autoimmune disorders may reveal previously unrecognized regulators of immune cell functions. A Crohn’s disease risk allele was associated with increased expression in T lymphocytes of the adapter protein Src kinase–associated phosphop...