Institution
Institute for Research in Biomedicine
Recent research
- Health & MedicineOpen access
Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in neuroinflammation and Alzheimer’s disease (AD) pathophysiology, but its contribution to the phenotype associated with amyloid precursor protein (APP) overexpression remains unclear. Here, we investigated the effects of...
- AI & ComputingOpen access
AB-DB v2.0: an integrated chemoinformatic resource for antimicrobial compounds
Abstract Antibiotic resistance is a major threat to public health and calls for chemoinformatic tools that can help the design of antibacterial discovery libraries. We present AB-DB v2.0, a freely available online database of molecular dynamics (MD) trajectories, quantum-mechanic...
- BiologyOpen access
Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic simulations of chromatin...
- Health & MedicineOpen access
Abstract Purpose Pediatric-type diffuse high-grade gliomas (pHGG) are aggressive, largely incurable malignancies often characterized by PI3K/AKT pathway activation. This study investigated whether the PI3K inhibitor inavolisib and the AKT inhibitor ipatasertib could achieve thera...
- BiologyOpen access
Abstract Background and aims Metabolomics offers a promising approach to objectively assess food intake and nutrition-related health risks. Three different dietary patterns (DPs) associated with cardiometabolic health were previously identified at 2 years of age in the EU Childho...
- Health & MedicineOpen access
Autologous platelet-rich plasma (PRP) is commonly used to enhance tissue repair. Its effectiveness may be limited by the patient’s individual condition. Given that aging impacts tissue regeneration, it is important to analyze the composition of the PRP obtained from elderly indiv...
- Health & MedicineOpen access
Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids
BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...