Institute for Neurosciences of Montpellier

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

210Pbex in lacustrine sediments: A half-century global synthesis (1977-2024)

Unsupported 210 Pb ( 210 Pb ex ) is a naturally occurring radionuclide widely used to establish sediment chronologies spanning the past ∼150 years, thereby providing high-resolution temporal frameworks for palaeolimnological reconstructions. Since the late 1970s, numerous hypothe...

Combined Idiopathic Intracranial Hypertension score, an integrated severity and treatment-oriented tool for idiopathic intracranial hypertension: a retrospective cohort study

IIH has evolved into a multidisciplinary condition managed across neurology, ophthalmology, interventional neuroradiology, and surgery. Existing tools address only partial aspects of disease severity; no unified, treatment-oriented classification exists to support multidisciplina...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Widespread circulation of West Nile and Usutu viruses in sedentary and migratory avifauna: A two-year study (2024–2025) of active surveillance in South of France

Abstract West Nile virus (WNV) and Usutu virus (USUV) are neurotropic Orthoflaviviruses sharing a similar enzootic transmission cycle primarily involving Culex pipiens mosquitoes as vectors and birds as amplifying hosts. First identified in Africa, both viruses established endemi...