Institute for Neurodegenerative Disorders

Neural signatures of major depression across the episodic memory circuitry.

In major depressive disorder (MDD), episodic memory is compromised and linked to hippocampal dysfunction, yet the underlying neural circuitry remains poorly understood. We examined the circuits supporting episodic memory and assessed its MDD-associated anatomical connectivity fin...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Association of Accelerated Biological Age in Midlife with Cardiovascular Events, Dementia, and All-Cause Mortality in the Framingham Offspring Study

Accelerated biological age (ABA) better capture the aging process than chronological age (CA) and has been linked to adverse health outcomes, but long-term associations remain unclear. We modeled ABA using anthropometric and biochemical biomarkers across three examination cycles...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...