Institute for Molecular Systems Biology

Overconsumption of low-digestible sugars can increase susceptibility to Salmonella Typhimurium infection

Abstract Low-digestible carbohydrates (LDCs), including dietary fibers and sugars that resist absorption, are generally considered beneficial for the gut microbiota. However, we show that acute overconsumption of certain LDCs, particularly low-digestible sugars (LDSs), such as ar...

FDX1-independent non-canonical cuproptosis establishes a parallel mitochondria-centric death program

Abstract Objectives Copper is an essential redox cofactor required for mitochondrial respiration and antioxidant defense, yet its dysregulation creates a therapeutic vulnerability that can be exploited by copper active agents. Elesclomol and neocuproine are two potent copper acti...