Institution
Institute for Biomedicine
Recent research
- Health & MedicineOpen access
Dual Role of CACNA1C/CaV1.2 in Cardiac and Neuropsychiatric Disease
The CACNA1C gene encodes the α1C subunit of voltage-gated CaV1.2 calcium channels, serving many pivotal functions throughout the body, including in the heart and brain. Clinical and genetic evidence implicates altered expression and/or function of CACNA1C/CaV1.2 in both cardiac a...
- Health & Medicine
Abstract Histoplasma capsulatum, a dimorphic fungus, is the causative agent of histoplasmosis, a respiratory disease with a wide clinical spectrum ranging from asymptomatic infection to severe pulmonary or disseminated disease. Although Ecuador is recognized as an endemic country...
- Health & Medicine
Background Hypertension is a multifactorial condition that is likely to affect older adults. We evaluated the effects of home-based isometric handgrip training (IHT) or aerobic exercise training (AET) on vascular health of older adults with elevated blood pressure (BP) and hypert...
- BiologyOpen access
ABSTRACT CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we develope...
- Biology
T cell–intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models
Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role rem...