Institute for Biomedical Research and Innovation

I casi studio per testare utilità e validità dell'Atlante Aria Salute: definizione del quadro concettuale.

OBJECTIVES: to describe the process of selecting and applying a shared conceptual model for the analysis of case studies designed to test the usefulness and validity of the Air and Health Atlas in supporting decision-making, in its current version and in its potential future deve...

Extracellular vesicles in targeted drug delivery: from biological functions to surface engineering

Abstract Achieving precise and efficient targeting represents a major challenge in drug delivery to overcome the limitations of conventional therapies. Surface functionalization of extracellular vesicles (EVs)-nanosized membranous particles released by all cell types- has emerged...

Bacillus subtilis extracellular vesicles surface-displaying superoxide dismutase attenuate alcoholic liver injury by activating the Nrf2/HO-1 axis

Alcoholic liver disease (ALD) represents a globally prevalent progressive hepatic disorder with continuously rising incidence. Its pathological mechanisms mainly stem from the direct toxic effects of alcohol metabolites, accompanied by aggravated oxidative stress, lipid overaccum...

Molecular Characterization of Natural Populations of Glycyrrhiza glabra L. (Fabaceae) in the Provinces of Agrigento and Trapani (Sicily, Italy, Europe)

Glycyrrhiza glabra is an herbaceous plant native to Eurasia, living in mild climates, and spread worldwide. Liquorice serves as a vital resource for human health, used as medicinal plants in feed and food, with anti-inflammatory and anticancer properties. To the best of our knowl...

The isolated HEPN domain of SACSIN exhibits RNA-binding activity

Abstract Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) is a neurodegenerative disorder caused by mutations in the SACS gene, though the molecular function of its protein product, SACSIN, remains elusive. Therapeutic strategies for ARSACS are limited, mostly d...

LaMn1−xNixO3 Perovskite Deposited on γ-Al2O3 Spheres as Catalyst for Dry Reforming of Methane

Dry reforming of methane (DRM) represents a promising route for the valorization of CO2 captured from industrial emissions through high-temperature catalytic conversion. In this work, a LaMn1−xNixO3 perovskite catalyst (x = 0.25, 6 wt% Ni) was synthesized as a powder by solution...

Expiratory phase lung mechanics in late-onset Pompe disease: a multicenter study using oscillometry to identify specific breathing abnormalities

Abstract Introduction In late-onset Pompe disease (LOPD), muscle weakness causes restrictive lung impairment. In murine models, glycogen deposition in lung parenchyma suggests additional causes for restriction that remain poorly understood. We investigated whether oscillometry de...