Institute for Advanced Medical Research

TomoMamba: a two-stage model with state-space cross-slice propagation for breast cancer diagnosis in digital breast tomosynthesis

Abstract Digital breast tomosynthesis (DBT) provides volumetric image stacks that improve lesion conspicuity compared with two-dimensional (2D) mammography, yet most automated methods process slices independently and discard the depth-wise continuity that underpins this advantage...

Scale-Dependent Disformal Dark Matter: Resolving Cosmic Tensions with S-Matrix Positivity and Gravitational Wave Invariance

We present a fully covariant, scale-dependent disformal coupling within the dark sector (SD-DDM) designed to simultaneously resolve the Hubble (H0) and clustering (S8) tensions. By strictly confining the Bekenstein disformal transformation to Cold Dark Matter (CDM) and preserving...

Scale-Dependent Disformal Dark Matter: Resolving Cosmic Tensions with S-Matrix Positivity and Gravitational Wave Invariance

We present a fully covariant, scale-dependent disformal coupling within the dark sector (SD-DDM) designed to simultaneously resolve the Hubble (H0) and clustering (S8) tensions. By strictly confining the Bekenstein disformal transformation to Cold Dark Matter (CDM) and preserving...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Chemical Stabilizationand Transformation of SchiffBase Scaffold: A Path toward Superior Platinum-Based Anti-Cancer StemCell Drugs

Abstract The clinical application of platinum-based anticancer agents is limited by poor aqueous stability, low solubility, and dose-limiting toxicities. Here, we report two Pt(II) complexes based on a Schiff base ligand and its reduced imine derivative, designed to overcome thes...

CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles

Chimeric antigen receptor (CAR) technology has revolutionized B-cell malignancy treatment by enabling T cells to effectively recognize and target lineage-specific surface antigens. However, CAR T cells show limited efficacy against myeloid neoplasms and solid tumors due to challe...

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation

The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Signif...